Idiopathic male infertility in correlation with oxidative stress (OS) – based on analysis of diagnostic data

Abstract

The study includes a retrospective study of male infertility using infertility clinic medical records due to a lack of epidemiological data or studies on the causes of infertility. The aim was to elucidate the causes of the prevalence of infertility and to systematically review the literature to elucidate the effects of oxidative stress (OS) on male infertility and the possibilities of measuring the active oxygen form (ROS) that could be used in daily clinical practice. The algorithm for diagnosing male infertility was developed based on research and recommendations from the Cleveland Clinic Algorithm. The test was performed according to a diagnostic algorithm for sperm analysis and OS evaluation. The male infertility oxidation system (MiOXSYS) was used to detect OS. Results: In the study, 718 couples were referred to the Infertility Clinic for reasons related to male infertility - 234 cases (32.59%) as the leading cause of infertility. Idiopathic sperm abnormalities were identified in 124 cases (89.86%). Based on semen analysis, MiOXSYS was performed in 106 men who reported infertility for the first time. Sperm pathology was detected in 71 cases (67%), of which OS - 57 (80%). Normozoospermia was detected in 35 cases (33%), of which 16 in OS (46%).