Associations of prenatally detected choroid plexus cysts with biochemical risk for congenital disorders

Abstract

Background: The choroid plexus cysts are one of the fetus ultrasonography findings which concerns parents about their child’s health. Usually cysts are found in an estimated number 1 % all performed ultrasonographies. The aim of the study to evaluate the risk of Down, Edwards syndromes and neural tube defect when choroid plexus cyst is found. Materials and Methods: There were calculated risks of Down, Edward’s syndromes and neural tube defect (NTD) by using second trimester biomarkers (alpha fetoprotein, human choriongonadotropin, free nonconjugated estriol) for patients with choroid plexus cysts. A control group was selected randomly with calculated risks and without any abnormal ultrasonography findings. These risks were compared between these two groups. Results: 12 pregnancies with diagnosed CPC were included in this study during the year 2012. By comparing calculated risks for chromosomal abnormalities and NTD between test and control groups, we found out that there are no statistical significant difference. Conclusion: There is no statistically significant data that choroid plexus cysts increases the risk of Down, Edwards syndromes and neural tube defect.